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spike?protein RBD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (6)
By Research Areas:	Infection (6)

6

Inhibitors & Agonists

5

Inhibitory Antibodies

8

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*Anti-Spike-RBD mAb* 1 Publications Verification SARS-CoV-2 (2019-nCoV) Spike RBD Antibody	SARS-CoV	Infection
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .

Amubarvimab BRII-196	SARS-CoV	Infection
Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of *spike protein, with a K_D* of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants .

HY-149256

PLpro/RBD-IN-1

SARS-CoV Infection

PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively .

Beludavimab BMS 4182137; VIR 7832	SARS-CoV	Infection
Beludavimab (BMS 4182137; VIR 7832) is a monoclonal antibody targeting the spike glycoprotein of SARS-CoV-2. Beludavimab binds to recombinant spike protein receptor-binding domain (S-RBD) with an EC₅₀ value of 14.9 ng/mL and a K_d of 0.21 nM .

Masavibart ZRC3308-A7	SARS-CoV	Infection
Masavibart (ZRC3308-A7) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on the *RBD* of the SARS-CoV-2 spike protein. Masavibart can be used in combination with ZRC3308-B10 (HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease .

Nepuvibart ZRC3308-B10	SARS-CoV	Infection
Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the *RBD* of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease .

Species:	Virus (8)
Tag:	His (6) Avi (6) Fc (3)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

	SARS-CoV-2 S glycoprotein (HEK293, His-mFc) Spike glycoproteinRBD; ,Spike Protein RBD;	Virus	HEK293
	The SARS-CoV-2 S glycoprotein is critical in infection, binding to the ACE2 receptor and allowing viral particles to attach to the host cell membrane. Cleavage of S2/S2′ triggers cell membrane fusion or internalization via endocytosis. SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is the recombinant Virus-derived SARS-CoV-2 S glycoprotein, expressed by HEK293 , with C-mFc, C-6*His labeled tag. The total length of SARS-CoV-2 S glycoprotein (HEK293, His-mFc) is 223 a.a., with molecular weight (glycosylation form) of ~66.0 kDa.

	*SARS-COV-2 S Protein* RBD (HEK293, His-Avi)** S protein RBD; S glycoprotein RBD; Spike protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S Protein RBD (HEK293, His-Avi) is the recombinant Virus-derived SARS-COV-2 S protein RBD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-COV-2 S Protein RBD (HEK293, His-Avi) is 214 a.a., with molecular weight of 32-42 kDa.

	*SARS-CoV-2 S Protein* RBD (Biotinylated, HEK293, Fc-Avi)** S protein RBD; S glycoprotein RBD; Spike protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 S Protein RBD (Biotinylated, HEK293, Fc-Avi) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of SARS-CoV-2 S Protein RBD (Biotinylated, HEK293, Fc-Avi) is 214 a.a., with molecular weight of 60-62 kDa.

	*SARS-CoV S Protein* RBD (HEK293, His-Avi)** S protein RBD; S glycoprotein RBD; Spike protein RBD	Virus	HEK293
	The SARS-CoV S protein coordinates viral entry by interacting with human ACE2 and CLEC4M/DC-SIGNR receptors to attach viral particles to the cell membrane. It downregulates host tethering protein (BST2) through lysosomal degradation, antagonizing its antiviral activity. SARS-CoV S Protein RBD (HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV S protein RBD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-CoV S Protein RBD (HEK293, His-Avi) is 222 a.a., with molecular weight of 36-46 kDa.

	*SARS-CoV S Protein* RBD (Biotinylated, HEK293, His-Avi)** S protein RBD; S glycoprotein RBD; Spike protein RBD	Virus	HEK293
	The SARS-CoV S protein coordinates viral entry by interacting with human ACE2 and CLEC4M/DC-SIGNR receptors to attach viral particles to the cell membrane. It downregulates host tethering protein (BST2) through lysosomal degradation, antagonizing its antiviral activity. SARS-CoV S Protein RBD (Biotinylated, HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV S protein RBD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-CoV S Protein RBD (Biotinylated, HEK293, His-Avi) is 222 a.a., with molecular weight of 36-46 kDa.

	*SARS-CoV-2 S Protein* RBD (N501Y, K417N, E484K, HEK293, His)** S protein RBD; S glycoprotein RBD; Spike protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 S Protein RBD (N501Y, K417N, E484K, HEK293, His) is the recombinant Virus-derived SARS-CoV-2 S protein RBD, expressed by HEK293 , with C-His labeled tag. The total length of SARS-CoV-2 S Protein RBD (N501Y, K417N, E484K, HEK293, His) is 223 a.a., with molecular weight of 30-40 kDa.

	*SARS-CoV S1 Protein* RBD (Biotinylated, HEK293, His-Avi)** S1 protein; Spike protein S1; Spike,S1 protein; S glycoprotein Subunit1	Virus	HEK293
	The SARS-CoV S protein coordinates viral entry by interacting with human ACE2 and CLEC4M/DC-SIGNR receptors to attach viral particles to the cell membrane. It downregulates host tethering protein (BST2) through lysosomal degradation, antagonizing its antiviral activity. SARS-CoV S1 Protein RBD (Biotinylated, HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV S1 protein RBD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-CoV S1 Protein RBD (Biotinylated, HEK293, His-Avi) is 654 a.a., with molecular weight of 120-140 kDa.

	*SARS-CoV S1 Protein* RBD (Biotinylated, HEK293, Fc-Avi)** S1 protein; Spike protein S1; Spike,S1 protein; S glycoprotein Subunit1	Virus	HEK293
	The SARS-CoV S protein coordinates viral entry by interacting with human ACE2 and CLEC4M/DC-SIGNR receptors to attach viral particles to the cell membrane. It downregulates host tethering protein (BST2) through lysosomal degradation, antagonizing its antiviral activity. SARS-CoV S1 Protein RBD (Biotinylated, HEK293, Fc-Avi) is the recombinant Virus-derived SARS-CoV S1 protein RBD, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of SARS-CoV S1 Protein RBD (Biotinylated, HEK293, Fc-Avi) is 654 a.a., with molecular weight of 120-140 kDa.

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